Sugammadex

Sugammadex: A Comprehensive Analysis

Sugammadex is a selective relaxant-binding agent (SRBA) used for the reversal of neuromuscular blockade induced by aminosteroid non-depolarising neuromuscular blocking agents (NMBAs) such as rocuronium and vecuronium. Compared to traditional anticholinesterase agents, Sugammadex provides a faster, more predictable, and complete reversal with fewer adverse effects. The introduction of Sugammadex has significantly improved perioperative anaesthesia management, reducing postoperative complications associated with residual neuromuscular blockade.

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Neostigmine

Neostigmine: A Pharmacological and Clinical Review

Neostigmine, a reversible acetylcholinesterase inhibitor, has a well-established role in clinical medicine due to its ability to potentiate cholinergic transmission. It is extensively utilised for reversing non-depolarising neuromuscular blockade, managing myasthenia gravis, and stimulating gastrointestinal and urinary motility in postoperative settings. This article provides an advanced analysis of neostigmine’s pharmacokinetics, pharmacodynamics, dose calculations, clinical applications, and recent advancements in 2025.

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