Naloxone

Naloxone is a competitive opioid receptor antagonist with high affinity for the μ-opioid receptor, serving as the cornerstone pharmacological intervention for opioid-induced respiratory depression. Due to its essential role in acute opioid toxicity management, naloxone is widely utilised in both clinical and pre-hospital settings. This article provides an advanced review of naloxone’s pharmacological properties, therapeutic applications, dosage considerations, pharmacokinetics, pharmacodynamics, and its clinical utility in opioid overdose reversal. Special emphasis is placed on the implications of renal impairment, comparative efficacy with other opioid antagonists, and contemporary clinical guidelines.

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