Isoprenaline

Isoprenaline (isoproterenol) is a potent non-selective beta-adrenergic receptor agonist with widespread applications in cardiovascular and pulmonary medicine. As a synthetic catecholamine, isoprenaline exerts its physiological effects through stimulation of beta-1 adrenergic receptors in the myocardium, enhancing chronotropic and inotropic activity, and beta-2 receptors in the bronchial smooth muscle, facilitating bronchodilation. Due to its profound hemodynamic influence, isoprenaline is principally utilised in the management of severe bradycardia, atrioventricular (AV) block, and specific pulmonary conditions. Despite its historical prominence, contemporary therapeutic strategies have largely favoured more receptor-selective pharmacologic agents due to the non-selective nature of isoprenaline's adrenergic stimulation and associated risk of adverse effects.

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