Rifampicin

Rifampicin is a potent, broad-spectrum antibiotic classified under the rifamycin group. It has demonstrated remarkable efficacy against numerous bacterial infections, especially those involving Mycobacterium species. Mechanistically, Rifampicin targets the beta subunit of bacterial DNA-dependent RNA polymerase, thus inhibiting RNA synthesis and arresting microbial replication. Originally derived in the 1960s from Streptomyces rifamycinica, Rifampicin revolutionised the treatment of tuberculosis (TB) and remains a core element of anti-TB regimens. Thanks to its excellent oral bioavailability and tissue penetration, Rifampicin is widely employed in diverse healthcare contexts globally.

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